node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADL57789.1 | ADL57790.1 | MTBMA_c01800 | MTBMA_c01810 | Predicted FeMo cofactor biosynthesis protein. | Predicted iron-sulfur flavoprotein. | 0.867 |
ADL57789.1 | ADL57791.1 | MTBMA_c01800 | MTBMA_c01820 | Predicted FeMo cofactor biosynthesis protein. | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.856 |
ADL57789.1 | ADL57793.1 | MTBMA_c01800 | MTBMA_c01840 | Predicted FeMo cofactor biosynthesis protein. | Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.704 |
ADL57789.1 | asnB | MTBMA_c01800 | MTBMA_c08090 | Predicted FeMo cofactor biosynthesis protein. | Asparagine synthase; Glutamine-hydrolyzing. | 0.516 |
ADL57789.1 | rtcB | MTBMA_c01800 | MTBMA_c01830 | Predicted FeMo cofactor biosynthesis protein. | Conserved hypothetical protein; Belongs to the RtcB family. | 0.836 |
ADL57790.1 | ADL57789.1 | MTBMA_c01810 | MTBMA_c01800 | Predicted iron-sulfur flavoprotein. | Predicted FeMo cofactor biosynthesis protein. | 0.867 |
ADL57790.1 | ADL57791.1 | MTBMA_c01810 | MTBMA_c01820 | Predicted iron-sulfur flavoprotein. | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.862 |
ADL57790.1 | ADL57793.1 | MTBMA_c01810 | MTBMA_c01840 | Predicted iron-sulfur flavoprotein. | Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.725 |
ADL57790.1 | rtcB | MTBMA_c01810 | MTBMA_c01830 | Predicted iron-sulfur flavoprotein. | Conserved hypothetical protein; Belongs to the RtcB family. | 0.845 |
ADL57791.1 | ADL57789.1 | MTBMA_c01820 | MTBMA_c01800 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Predicted FeMo cofactor biosynthesis protein. | 0.856 |
ADL57791.1 | ADL57790.1 | MTBMA_c01820 | MTBMA_c01810 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Predicted iron-sulfur flavoprotein. | 0.862 |
ADL57791.1 | ADL57793.1 | MTBMA_c01820 | MTBMA_c01840 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.802 |
ADL57791.1 | ADL58044.1 | MTBMA_c01820 | MTBMA_c04430 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Translation initiation factor aIF-2B, subunit alpha; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.969 |
ADL57791.1 | ADL59361.1 | MTBMA_c01820 | MTBMA_c17930 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Predicted aldolase. | 0.640 |
ADL57791.1 | apt | MTBMA_c01820 | MTBMA_c17060 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | 0.658 |
ADL57791.1 | asnB | MTBMA_c01820 | MTBMA_c08090 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Asparagine synthase; Glutamine-hydrolyzing. | 0.662 |
ADL57791.1 | dadD | MTBMA_c01820 | MTBMA_c00900 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Predicted amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deo [...] | 0.980 |
ADL57791.1 | guaAB | MTBMA_c01820 | MTBMA_c11000 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | GMP synthase, subunit B; Catalyzes the synthesis of GMP from XMP. | 0.654 |
ADL57791.1 | rtcB | MTBMA_c01820 | MTBMA_c01830 | Predicted phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Conserved hypothetical protein; Belongs to the RtcB family. | 0.929 |
ADL57793.1 | ADL57789.1 | MTBMA_c01840 | MTBMA_c01800 | Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Predicted FeMo cofactor biosynthesis protein. | 0.704 |