STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA2Predicted 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (391 aa)    
Predicted Functional Partners:
leuC1
Predicted 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 
 0.995
ADL58232.1
Isopropylmalate dehydrogenase related protein.
  
 0.973
leuD1
3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...]
  
 
 0.972
atoB
acetyl-CoA acetyltransferase.
  
 
 0.946
acsA1
Predicted acetyl-coenzyme A synthetase.
  
 
 0.933
acsA2
Acetyl-coenzyme A synthetase.
  
 
 0.933
acs
acyl-CoA synthetase; AMP-forming.
  
 
 0.933
korA
2-oxoglutarate synthase, subunit alpha.
  
 
 0.924
porB1
Pyruvate synthase, subunit B.
  
 
 0.922
porA2
Predicted pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha.
  
 
 0.922
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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