STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iorBIndolepyruvate oxidoreductase, subunit beta; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (196 aa)    
Predicted Functional Partners:
iorA
Indolepyruvate oxidoreductase, subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
 
 0.997
porB2
Predicted pyruvate flavodoxin/ferredoxin oxidoreductase, subunit beta.
  
 
 0.886
korB
2-oxoglutarate synthase, subunit beta.
  
 
 0.886
porB1
Pyruvate synthase, subunit B.
  
 
 0.876
korA
2-oxoglutarate synthase, subunit alpha.
 
 
 0.844
vorB
2-oxoisovalerate oxidoreductase, subunit beta.
  
 
 0.821
porA2
Predicted pyruvate flavodoxin/ferredoxin oxidoreductase, subunit alpha.
  
 
 0.811
porA1
Pyruvate synthase, subunit A.
  
 
 0.804
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
   
 
 0.760
tfrB
Thiol:fumarate reductase, subunit B; Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.
  
  
 0.661
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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