Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pycAPyruvate carboxylase, subunit A. (491 aa)    
Predicted Functional Partners:
pycB
Pyruvate carboxylase, subunit B.
 
 
 0.999
birA
Predicted biotin ligase.
 
 0.994
ppcA
Phosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
  
  
 0.949
korA
2-oxoglutarate synthase, subunit alpha.
  
 
  0.919
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD(+) and NADP(+) with similar specific activity. Belongs to the LDH/MDH superfamily.
    
 0.915
korB
2-oxoglutarate synthase, subunit beta.
    
 0.914
porC
Pyruvate synthase, subunit C.
    
 0.913
porB2
Predicted pyruvate flavodoxin/ferredoxin oxidoreductase, subunit beta.
    
 0.913
porB1
Pyruvate synthase, subunit B.
    
 0.911
porA1
Pyruvate synthase, subunit A.
  
 
  0.910
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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