node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADL58144.1 | ADL58145.1 | MTBMA_c05490 | MTBMA_c05500 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.855 |
ADL58144.1 | aqpM | MTBMA_c05490 | MTBMA_c05510 | Conserved hypothetical protein. | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.955 |
ADL58145.1 | ADL58144.1 | MTBMA_c05500 | MTBMA_c05490 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.855 |
ADL58145.1 | aqpM | MTBMA_c05500 | MTBMA_c05510 | Conserved hypothetical protein. | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.876 |
ADL58253.1 | aqpM | MTBMA_c06580 | MTBMA_c05510 | Predicted hydrolase. | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.806 |
ADL59289.1 | aqpM | MTBMA_c17200 | MTBMA_c05510 | Predicted peptidyl-prolyl cis-trans isomerase. | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.770 |
ADL59289.1 | dnaJ | MTBMA_c17200 | MTBMA_c16760 | Predicted peptidyl-prolyl cis-trans isomerase. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.955 |
ADL59289.1 | dnaK | MTBMA_c17200 | MTBMA_c16750 | Predicted peptidyl-prolyl cis-trans isomerase. | Chaperone DnaK; Acts as a chaperone. | 0.862 |
ADL59289.1 | mdh | MTBMA_c17200 | MTBMA_c06400 | Predicted peptidyl-prolyl cis-trans isomerase. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD(+) and NADP(+) with similar specific activity. Belongs to the LDH/MDH superfamily. | 0.569 |
ADL59289.1 | ndk | MTBMA_c17200 | MTBMA_c07080 | Predicted peptidyl-prolyl cis-trans isomerase. | Predicted nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.907 |
ADL59289.1 | orfK | MTBMA_c17200 | MTBMA_c06100 | Predicted peptidyl-prolyl cis-trans isomerase. | Predicted peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. | 0.438 |
aqpM | ADL58144.1 | MTBMA_c05510 | MTBMA_c05490 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Conserved hypothetical protein. | 0.955 |
aqpM | ADL58145.1 | MTBMA_c05510 | MTBMA_c05500 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Conserved hypothetical protein. | 0.876 |
aqpM | ADL58253.1 | MTBMA_c05510 | MTBMA_c06580 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Predicted hydrolase. | 0.806 |
aqpM | ADL59289.1 | MTBMA_c05510 | MTBMA_c17200 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Predicted peptidyl-prolyl cis-trans isomerase. | 0.770 |
aqpM | dnaJ | MTBMA_c05510 | MTBMA_c16760 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.833 |
aqpM | dnaK | MTBMA_c05510 | MTBMA_c16750 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Chaperone DnaK; Acts as a chaperone. | 0.518 |
aqpM | grpE | MTBMA_c05510 | MTBMA_c16740 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...] | 0.501 |
aqpM | mdh | MTBMA_c05510 | MTBMA_c06400 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD(+) and NADP(+) with similar specific activity. Belongs to the LDH/MDH superfamily. | 0.600 |
aqpM | ndk | MTBMA_c05510 | MTBMA_c07080 | Aquaporin; Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Predicted nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.861 |