STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panPredicted proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promot [...] (410 aa)    
Predicted Functional Partners:
ADL58944.1
Conserved hypothetical protein.
  
 0.999
psmA
Predicted proteasome, subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.984
psmB
Predicted proteasome, subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.976
rpl40e
50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 0.967
htrA
Predicted serine protease HtrA.
  
 0.964
ADL58522.1
Predicted DNA double-strand repair ATPase Rad50.
   
 
 0.964
ADL58719.1
Predicted transcriptional regulator.
  
 
 0.777
cdcH
Predicted cell division protein 48.
 
0.750
ADL58674.1
Conserved hypothetical protein.
  
 
 0.734
rpl2p
50S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
  
 0.724
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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