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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADL58761.1Conserved hypothetical protein containing a ferredoxin domain. (376 aa)    
Predicted Functional Partners:
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
       0.678
thyA
Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate. In vitro, also catalyzes the dehalogenation of 5-bromo- deoxyuridine monophosphate (Br-dUMP) and the tritium exchange of [5- 3H]deoxyuridine monophosphate ([5-3H]dUMP).
       0.678
metE
Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate.
       0.669
ADL58765.1
Conserved hypothetical protein.
       0.665
ADL58766.1
Conserved hypothetical protein.
       0.665
ADL58767.1
Conserved hypothetical protein.
       0.603
ADL58760.1
Conserved hypothetical protein.
       0.556
ADL58960.1
Predicted ATP-utilizing enzyme.
 
     0.556
ADL57997.1
Conserved hypothetical protein containing a ferredoxin domain.
 
     0.549
ADL59072.1
Conserved hypothetical protein; Belongs to the LarC family.
 
     0.524
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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