| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADL57618.1 | metE | MTBMA_c00060 | MTBMA_c11710 | Peroxiredoxin-related protein. | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate. | 0.968 |
| ADL58765.1 | ADL58766.1 | MTBMA_c11720 | MTBMA_c11730 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.915 |
| ADL58765.1 | metE | MTBMA_c11720 | MTBMA_c11710 | Conserved hypothetical protein. | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate. | 0.929 |
| ADL58765.1 | thyA | MTBMA_c11720 | MTBMA_c11700 | Conserved hypothetical protein. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate. In vitro, also catalyzes the dehalogenation of 5-bromo- deoxyuridine monophosphate (Br-dUMP) and the tritium exchange of [5- 3H]deoxyuridine monophosphate ([5-3H]dUMP). | 0.889 |
| ADL58766.1 | ADL58765.1 | MTBMA_c11730 | MTBMA_c11720 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.915 |
| ADL58766.1 | metE | MTBMA_c11730 | MTBMA_c11710 | Conserved hypothetical protein. | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate. | 0.916 |
| ADL58766.1 | thyA | MTBMA_c11730 | MTBMA_c11700 | Conserved hypothetical protein. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate. In vitro, also catalyzes the dehalogenation of 5-bromo- deoxyuridine monophosphate (Br-dUMP) and the tritium exchange of [5- 3H]deoxyuridine monophosphate ([5-3H]dUMP). | 0.851 |
| ADL58839.1 | ADL58840.1 | MTBMA_c12510 | MTBMA_c12520 | Conserved hypothetical protein containing a ferredoxin domain. | CBS domain containing protein. | 0.998 |
| ADL58839.1 | ahcY | MTBMA_c12510 | MTBMA_c02210 | Conserved hypothetical protein containing a ferredoxin domain. | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.900 |
| ADL58839.1 | hom | MTBMA_c12510 | MTBMA_c16200 | Conserved hypothetical protein containing a ferredoxin domain. | Predicted homoserine dehydrogenase. | 0.903 |
| ADL58839.1 | metE | MTBMA_c12510 | MTBMA_c11710 | Conserved hypothetical protein containing a ferredoxin domain. | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate. | 0.900 |
| ADL58840.1 | ADL58839.1 | MTBMA_c12520 | MTBMA_c12510 | CBS domain containing protein. | Conserved hypothetical protein containing a ferredoxin domain. | 0.998 |
| ADL58840.1 | ahcY | MTBMA_c12520 | MTBMA_c02210 | CBS domain containing protein. | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | 0.900 |
| ADL58840.1 | hom | MTBMA_c12520 | MTBMA_c16200 | CBS domain containing protein. | Predicted homoserine dehydrogenase. | 0.906 |
| ADL58840.1 | metE | MTBMA_c12520 | MTBMA_c11710 | CBS domain containing protein. | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate. | 0.901 |
| ahcY | ADL58839.1 | MTBMA_c02210 | MTBMA_c12510 | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | Conserved hypothetical protein containing a ferredoxin domain. | 0.900 |
| ahcY | ADL58840.1 | MTBMA_c02210 | MTBMA_c12520 | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | CBS domain containing protein. | 0.900 |
| ahcY | hom | MTBMA_c02210 | MTBMA_c16200 | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | Predicted homoserine dehydrogenase. | 0.849 |
| ahcY | metE | MTBMA_c02210 | MTBMA_c11710 | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate. It was proposed that, in vivo, a so-far-unidentified enzyme catalyzes methyltransfer from 5- methyltetrahydromethanopterin (5-CH3-H4MPT) to a corrinoid protein, and that the MetE gene product catalyzes the further transfer to L- homocysteine. Is not active with L-cysteine, coenzyme M, coenzyme B, glutathione or dithiothreitol as substrate. | 0.981 |
| ahcY | metS | MTBMA_c02210 | MTBMA_c09670 | S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.484 |
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