STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumA2Fumarase related protein. (280 aa)    
Predicted Functional Partners:
ADL59078.1
Predicted fumarate hydratase.
 
 
 0.984
fumA1
Fumarate hydratase.
 
 
 0.982
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can use NAD(+) and NADP(+) with similar specific activity. Belongs to the LDH/MDH superfamily.
  
 
 0.961
tfrA
Thiol:fumarate reductase, subunit A; Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen; Belongs to the FAD-dependent oxidoreductase 2 family.
  
 
 0.960
tfrB
Thiol:fumarate reductase, subunit B; Catalyzes the reduction of fumarate with reduced coenzyme M (CoM-S-H) and coenzyme B (CoB-S-H). In vitro, is able to reduces fumarate with reduced benzyl viologen, oxidize CoM-S-H and CoB-S-H to CoM-S-S-CoB with methylene blue, and reduce CoM-S-S-CoB with reduced benzyl viologen. The enzyme has specificity for the two thiol compounds as the CoB--CoM heterodisulfide reductase. The enzyme is very sensitive to oxygen.
    
 0.952
ADL58937.1
Conserved hypothetical protein.
 
     0.929
ADL57916.1
Predicted fumarate hydratase.
  
  
 
0.925
gltA
Predicted citrate synthase.
  
  
 0.852
ADL58938.1
2-methylcitrate dehydratase related protein.
 
  
 0.838
argH
Argininosuccinate lyase.
    
 0.829
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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