flpA protein (Methanothermobacter marburgensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

flpA

Predicted fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (221 aa)

Predicted Functional Partners:

nop56

0.998

rpl7ae

0.959

rpl13p

0.958

fusA

0.954

rps4p

0.945

ADL59289.1

0.942

rps9p

0.936

ADL58975.1

0.931

rpl3p

0.924

ADL58843.1

0.919

Your Current Organism:

Methanothermobacter marburgensis

NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADL58843.1	ADL58975.1	MTBMA_c12550	MTBMA_c13880	Predicted GTPase.	Predicted RNA-binding protein.	0.701
ADL58843.1	flpA	MTBMA_c12550	MTBMA_c16000	Predicted GTPase.	Predicted fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.	0.919
ADL58843.1	fusA	MTBMA_c12550	MTBMA_c14440	Predicted GTPase.	Protein translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF- [...]	0.549
ADL58843.1	nop56	MTBMA_c12550	MTBMA_c15990	Predicted GTPase.	Predicted ribosome biogenesis protein Nop56.	0.974
ADL58843.1	rpl13p	MTBMA_c12550	MTBMA_c05280	Predicted GTPase.	50S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.934
ADL58843.1	rpl3p	MTBMA_c12550	MTBMA_c04910	Predicted GTPase.	50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	0.967
ADL58843.1	rpl7ae	MTBMA_c12550	MTBMA_c07050	Predicted GTPase.	50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.916
ADL58843.1	rps4p	MTBMA_c12550	MTBMA_c05240	Predicted GTPase.	30S ribosomal protein S4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.570
ADL58843.1	rps9p	MTBMA_c12550	MTBMA_c05290	Predicted GTPase.	30S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family.	0.923
ADL58975.1	ADL58843.1	MTBMA_c13880	MTBMA_c12550	Predicted RNA-binding protein.	Predicted GTPase.	0.701
ADL58975.1	ADL59289.1	MTBMA_c13880	MTBMA_c17200	Predicted RNA-binding protein.	Predicted peptidyl-prolyl cis-trans isomerase.	0.728
ADL58975.1	flpA	MTBMA_c13880	MTBMA_c16000	Predicted RNA-binding protein.	Predicted fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.	0.931
ADL58975.1	fusA	MTBMA_c13880	MTBMA_c14440	Predicted RNA-binding protein.	Protein translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF- [...]	0.431
ADL58975.1	nop56	MTBMA_c13880	MTBMA_c15990	Predicted RNA-binding protein.	Predicted ribosome biogenesis protein Nop56.	0.988
ADL58975.1	rpl3p	MTBMA_c13880	MTBMA_c04910	Predicted RNA-binding protein.	50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	0.417
ADL58975.1	rpl7ae	MTBMA_c13880	MTBMA_c07050	Predicted RNA-binding protein.	50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.945
ADL58975.1	rps4p	MTBMA_c13880	MTBMA_c05240	Predicted RNA-binding protein.	30S ribosomal protein S4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.998
ADL58975.1	rps9p	MTBMA_c13880	MTBMA_c05290	Predicted RNA-binding protein.	30S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family.	0.948
ADL59289.1	ADL58975.1	MTBMA_c17200	MTBMA_c13880	Predicted peptidyl-prolyl cis-trans isomerase.	Predicted RNA-binding protein.	0.728
ADL59289.1	flpA	MTBMA_c17200	MTBMA_c16000	Predicted peptidyl-prolyl cis-trans isomerase.	Predicted fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.	0.942

page 1 of 6

Server load: low (34%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About