| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADL59270.1 | ADL59274.1 | MTBMA_c17010 | MTBMA_c17050 | Predicted ADP-ribose pyrophosphatase. | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.652 |
| ADL59270.1 | apt | MTBMA_c17010 | MTBMA_c17060 | Predicted ADP-ribose pyrophosphatase. | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | 0.680 |
| ADL59270.1 | csl4 | MTBMA_c17010 | MTBMA_c17040 | Predicted ADP-ribose pyrophosphatase. | Predicted RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.892 |
| ADL59270.1 | pcnA | MTBMA_c17010 | MTBMA_c16980 | Predicted ADP-ribose pyrophosphatase. | DNA polymerase sliding clamp PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.596 |
| ADL59270.1 | rpoL | MTBMA_c17010 | MTBMA_c17030 | Predicted ADP-ribose pyrophosphatase. | DNA-directed RNA polymerase, subunit L. | 0.908 |
| ADL59270.1 | rpoM | MTBMA_c17010 | MTBMA_c17000 | Predicted ADP-ribose pyrophosphatase. | Predicted DNA-directed RNA polymerase, subunit M; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.743 |
| ADL59274.1 | ADL59270.1 | MTBMA_c17050 | MTBMA_c17010 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Predicted ADP-ribose pyrophosphatase. | 0.652 |
| ADL59274.1 | apt | MTBMA_c17050 | MTBMA_c17060 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | 0.944 |
| ADL59274.1 | csl4 | MTBMA_c17050 | MTBMA_c17040 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Predicted RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.814 |
| ADL59274.1 | dphB | MTBMA_c17050 | MTBMA_c04450 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Predicted diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.878 |
| ADL59274.1 | fusA | MTBMA_c17050 | MTBMA_c14440 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Protein translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF- [...] | 0.996 |
| ADL59274.1 | pcnA | MTBMA_c17050 | MTBMA_c16980 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA polymerase sliding clamp PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.577 |
| ADL59274.1 | pus10 | MTBMA_c17050 | MTBMA_c17080 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Predicted pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. | 0.694 |
| ADL59274.1 | rpoL | MTBMA_c17050 | MTBMA_c17030 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase, subunit L. | 0.768 |
| ADL59274.1 | rpoM | MTBMA_c17050 | MTBMA_c17000 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Predicted DNA-directed RNA polymerase, subunit M; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.624 |
| ADL59274.1 | srp54 | MTBMA_c17050 | MTBMA_c17070 | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Signal recognition particle protein Srp54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.712 |
| apt | ADL59270.1 | MTBMA_c17060 | MTBMA_c17010 | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | Predicted ADP-ribose pyrophosphatase. | 0.680 |
| apt | ADL59274.1 | MTBMA_c17060 | MTBMA_c17050 | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | Predicted diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.944 |
| apt | csl4 | MTBMA_c17060 | MTBMA_c17040 | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | Predicted RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.766 |
| apt | pus10 | MTBMA_c17060 | MTBMA_c17080 | Predicted adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Prefers hypoxanthine, has 66% activity with guanine while activity with adenine, xanthine, uracil, orotate, or cytosine is negligible. | Predicted pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. | 0.671 |
STRING v12.5 is now available!
