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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rubcnRubicon autophagy regulator. (933 aa)    
Predicted Functional Partners:
ENSAMXP00000045176
UV radiation resistance associated gene.
    
 
 0.957
pik3c3
Phosphatidylinositol 3-kinase catalytic subunit type 3.
    
 
 0.954
Becn1
Beclin 1, autophagy related.
    
 
 0.937
pik3r4
Phosphoinositide-3-kinase, regulatory subunit 4.
    
 
 0.837
ATG14
Autophagy related 14.
    
 
 0.715
rab7a
Uncharacterized protein.
    
 
 0.668
LOC103037223
RAB7b, member RAS oncogene family.
    
 
 0.668
LOC103043048
RAB7a, member RAS oncogene family.
    
 
 0.668
ambra1
Autophagy/beclin-1 regulator 1b.
   
 
 0.551
atg7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
   
  
 0.529
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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