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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hpse2Heparanase 2. (571 aa)    
Predicted Functional Partners:
hpse
Heparanase.
  
  
 
0.902
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.591
lrig2
Leucine-rich repeats and immunoglobulin-like domains 2.
      
 0.576
LOC103040550
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.566
SDC3
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.531
ENSAMXP00000042222
Heparan sulfate proteoglycan 2.
     
 0.450
sdc4
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
     
 0.441
gpc5
Glypican 5a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
     
 0.439
LOC103034168
Glypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
     
 0.439
Agrn
Agrin.
     
 0.433
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.