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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lrp1bLow density lipoprotein receptor-related protein 1Bb. (4546 aa)    
Predicted Functional Partners:
Agrn
Agrin.
    
 0.693
RELN
Reelin.
    
 0.644
Ldlrap1
Low density lipoprotein receptor adaptor protein 1b.
    
 0.636
W5K2Q9_ASTMX
Kringle containing transmembrane protein 1.
    
 0.633
pcsk9
Proprotein convertase subtilisin/kexin type 9.
    
 0.625
ENSAMXP00000042222
Heparan sulfate proteoglycan 2.
   
0.608
Wnt4
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
    
 0.605
LOC103035380
Uncharacterized protein.
     
 0.600
dab1
DAB adaptor protein 1a.
    
 0.595
W5KJM9_ASTMX
Uncharacterized protein.
    
 0.583
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.