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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
megf11Multiple EGF-like-domains 11. (1114 aa)    
Predicted Functional Partners:
ENSAMXP00000043144
GULP PTB domain containing engulfment adaptor 1b.
   
 
 0.530
ENSAMXP00000049605
GULP PTB domain containing engulfment adaptor 1a.
   
 
 0.530
W5KS38_ASTMX
Uncharacterized protein.
    
 
0.516
W5LFW3_ASTMX
Laminin, alpha 1.
    
 
0.516
ENSAMXP00000039855
Uncharacterized protein.
    
  0.516
LOC103036059
Platelet endothelial aggregation receptor 1.
  
  
 
0.512
itgb4
Integrin beta.
   
 0.491
LOC103032002
Integrin, alpha 3a; Belongs to the integrin alpha chain family.
    
 0.481
LOC103040573
Integrin, alpha 3b; Belongs to the integrin alpha chain family.
    
 0.481
W5KNT0_ASTMX
Si:ch211-241e1.3.
    
  0.457
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.