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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103034135Insulin receptor substrate 2b. (1102 aa)    
Predicted Functional Partners:
LOC103045439
Tyrosine-protein kinase receptor.
   
 0.972
LOC103037538
Tyrosine-protein kinase receptor.
   
 0.972
LOC103039445
Tyrosine-protein kinase receptor.
   
 0.970
LOC103046713
Growth factor receptor-bound protein 2a.
    
 0.967
LOC111191028
Growth factor receptor-bound protein 2b.
    
 0.967
Ins
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
     
 0.946
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
 0.928
chuk
Component of inhibitor of nuclear factor kappa B kinase complex.
    
 0.919
ptpn1
Protein tyrosine phosphatase non-receptor type 1.
    
 0.915
LOC103047157
Suppressor of cytokine signaling 3a.
    
 0.912
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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