close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plekhh2Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2. (1426 aa)    
Predicted Functional Partners:
plekhf2
Pleckstrin homology domain containing, family F (with FYVE domain) member 2.
      
 0.574
neurl1b
Neuralized E3 ubiquitin protein ligase 1B.
      
 0.563
rfc3
Replication factor C (activator 1) 3.
   
  
 0.515
shisa3
Shisa family member 3.
      
 0.515
PLEKHG1
Pleckstrin homology and RhoGEF domain containing G1.
      
 0.493
nop53
Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.
      
 0.481
tox4
TOX high mobility group box family member 4 b.
      
 0.481
Zfyve26
Zinc finger, FYVE domain containing 26.
      
 0.437
Brca2
BRCA2 DNA repair associated.
      
 0.418
Fam43a
Family with sequence similarity 43 member A.
      
 0.412
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.