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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arhgef2Rho/rac guanine nucleotide exchange factor (GEF) 2. (1185 aa)    
Predicted Functional Partners:
Cgn
Si:dkey-238m4.3.
     
 0.973
LOC103031338
Ras homolog family member Cb.
   
 0.972
LOC103028705
Ras homolog gene family, member Aa.
   
 0.972
LOC103029431
Uncharacterized protein.
   
 0.972
LOC103035456
Ras homolog family member Ca.
   
 0.972
LOC103027457
Ras homolog gene family, member Ab.
   
 0.972
LOC103028124
Uncharacterized protein.
     
  0.900
LOC103042805
Cingulin b.
     
  0.900
RHOB
Ras homolog family member B.
   
 0.738
cdk1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
  
 0.597
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.