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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W5KB64_ASTMXWW domain containing transcription regulator 1. (385 aa)    
Predicted Functional Partners:
lats1
Large tumor suppressor kinase 1.
    
 0.947
lats2
Large tumor suppressor kinase 2.
    
 0.942
STK4
Serine/threonine kinase 4.
    
 0.876
stk3
Serine/threonine kinase 3 (STE20 homolog, yeast).
    
 0.876
W5L6R5_ASTMX
TEA domain-containing protein.
   
 0.860
tead1
TEA domain family member 1b.
   
 0.860
LOC103024231
TEA domain family member 1a.
   
 0.860
tead3
Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
   
 0.860
sav1
Salvador family WW domain containing protein 1.
    
 0.830
LOC103036249
Angiomotin.
    
 0.818
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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