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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdca7lCell division cycle associated 7b. (456 aa)    
Predicted Functional Partners:
wrn
WRN RecQ like helicase.
   
 0.971
rad17
RAD17 checkpoint clamp loader component.
   
 0.937
hus1
Checkpoint protein; Belongs to the HUS1 family.
    
 0.937
rad1
RAD1 homolog (S. pombe).
    
 0.937
Rfc2
Replication factor C (activator 1) 2.
   
 0.930
Rfc4
Replication factor C (activator 1) 4.
   
 0.926
rfc3
Replication factor C (activator 1) 3.
   
 0.914
ENSAMXP00000027946
SMC5-SMC6 complex localization factor 1.
    
 0.910
rfc5
Replication factor C (activator 1) 5.
   
 0.904
rpa1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.852
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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