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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cops3COP9 signalosome subunit 3. (423 aa)    
Predicted Functional Partners:
cops2
COP9 signalosome subunit 2.
   
 0.999
gps1
G protein pathway suppressor 1.
   
 0.999
COPS6
COP9 signalosome subunit 6.
   
 0.999
cops4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis).
   
 0.999
cops5
COP9 signalosome subunit 5.
   
 0.999
cops8
COP9 signalosome subunit 8.
   
 0.999
cops7a
COP9 constitutive photomorphogenic homolog subunit 7A.
    
 0.997
ppp1r42
Protein phosphatase 1, regulatory subunit 42.
   
 0.978
Rbx1
Ring-box 1, E3 ubiquitin protein ligase.
   
 0.945
cul2
Cullin 2; Belongs to the cullin family.
   
  0.935
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.