Lrp5 protein (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

Lrp5

Low density lipoprotein receptor-related protein 5. (1518 aa)

Predicted Functional Partners:

Wnt1

0.986

dkk1

0.974

ENSAMXP00000034556

0.973

fzd4

0.972

dkk2

0.971

sost

0.968

ENSAMXP00000041224

0.965

Wnt4

0.959

Fzd5

0.956

Fzd2

0.954

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000034556	Fzd2	ENSAMXP00000034556	ENSAMXP00000051921	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 2.	0.988
ENSAMXP00000034556	Fzd5	ENSAMXP00000034556	ENSAMXP00000026964	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.990
ENSAMXP00000034556	Lrp5	ENSAMXP00000034556	ENSAMXP00000005259	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Low density lipoprotein receptor-related protein 5.	0.973
ENSAMXP00000034556	Wnt1	ENSAMXP00000034556	ENSAMXP00000048816	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.601
ENSAMXP00000034556	Wnt4	ENSAMXP00000034556	ENSAMXP00000035119	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.586
ENSAMXP00000034556	dkk1	ENSAMXP00000034556	ENSAMXP00000018708	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dickkopf WNT signaling pathway inhibitor 1b.	0.933
ENSAMXP00000034556	dkk2	ENSAMXP00000034556	ENSAMXP00000041547	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dickkopf WNT signaling pathway inhibitor 2.	0.921
ENSAMXP00000034556	fzd4	ENSAMXP00000034556	ENSAMXP00000003771	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.993
ENSAMXP00000034556	sost	ENSAMXP00000034556	ENSAMXP00000009576	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Sclerostin.	0.492
ENSAMXP00000041224	Fzd2	ENSAMXP00000041224	ENSAMXP00000051921	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 2.	0.979
ENSAMXP00000041224	Fzd5	ENSAMXP00000041224	ENSAMXP00000026964	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.983
ENSAMXP00000041224	Lrp5	ENSAMXP00000041224	ENSAMXP00000005259	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Low density lipoprotein receptor-related protein 5.	0.965
ENSAMXP00000041224	Wnt1	ENSAMXP00000041224	ENSAMXP00000048816	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.601
ENSAMXP00000041224	Wnt4	ENSAMXP00000041224	ENSAMXP00000035119	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.586
ENSAMXP00000041224	dkk1	ENSAMXP00000041224	ENSAMXP00000018708	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dickkopf WNT signaling pathway inhibitor 1b.	0.877
ENSAMXP00000041224	dkk2	ENSAMXP00000041224	ENSAMXP00000041547	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Dickkopf WNT signaling pathway inhibitor 2.	0.915
ENSAMXP00000041224	fzd4	ENSAMXP00000041224	ENSAMXP00000003771	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.988
Fzd2	ENSAMXP00000034556	ENSAMXP00000051921	ENSAMXP00000034556	Frizzled class receptor 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.988
Fzd2	ENSAMXP00000041224	ENSAMXP00000051921	ENSAMXP00000041224	Frizzled class receptor 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.979
Fzd2	Fzd5	ENSAMXP00000051921	ENSAMXP00000026964	Frizzled class receptor 2.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.636