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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Lrp5Low density lipoprotein receptor-related protein 5. (1518 aa)    
Predicted Functional Partners:
sost
Sclerostin.
    
 0.991
LOC103032217
Dickkopf_N domain-containing protein.
    
 0.982
dkk1
Dickkopf WNT signaling pathway inhibitor 1b.
    
 0.982
ENSAMXP00000050565
Dickkopf WNT signaling pathway inhibitor 1a.
    
 0.982
dkk2
Dickkopf WNT signaling pathway inhibitor 2.
    
 0.978
fzd4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.952
Wnt1
Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.
    
 0.947
Fzd5
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.928
fzd3
Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.924
Fzd6
Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.924
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.