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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1250 aa)    
Predicted Functional Partners:
LOC103045202
Guanine nucleotide binding protein (G protein), alpha 14a.
    
 0.965
LOC103042808
Uncharacterized protein.
    
 0.965
LOC111191807
Guanine nucleotide binding protein (G protein), alpha 14.
    
 0.961
LOC103045689
Calcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily.
   
 
 0.944
prkcb
Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
     
 0.940
Itpr1
Inositol 1,4,5-trisphosphate receptor, type 1b.
   
 0.924
INPP5A
Inositol polyphosphate-5-phosphatase A.
   
 
 0.911
W5L6U8_ASTMX
Protein kinase C.
     
 0.909
LOC103032713
Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1.
   
 0.909
LOC103025973
Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
     
 0.907
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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