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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcm2Glial cells missing transcription factor 2. (493 aa)    
Predicted Functional Partners:
foxn1
Forkhead box N1.
    
 
 0.582
SYDE1
Synapse defective Rho GTPase homolog 1.
      
 0.579
hoxb9
Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.
      
 0.443
LOC103028240
Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.440
gen1
Uncharacterized protein.
      
 0.430
ret
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
   
 
 0.419
cpsf4
Cleavage and polyadenylation specific factor 4.
      
 0.416
mak
Male germ cell-associated kinase.
      
 0.403
ICK
Intestinal cell kinase.
      
 0.403
W5KX92_ASTMX
GLIS family zinc finger 2a.
    
 
 0.400
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.