close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
irs1Insulin receptor substrate 1. (1105 aa)    
Predicted Functional Partners:
Ins
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
     
 0.973
LOC103045439
Tyrosine-protein kinase receptor.
   
 0.972
LOC103037538
Tyrosine-protein kinase receptor.
   
 0.972
LOC103039445
Tyrosine-protein kinase receptor.
   
 0.970
LOC111191028
Growth factor receptor-bound protein 2b.
    
 0.968
LOC103046713
Growth factor receptor-bound protein 2a.
    
 0.967
pik3r1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).
    
 0.965
LOC103035767
Uncharacterized protein.
    
 0.965
ENSAMXP00000048538
Uncharacterized protein.
    
 0.965
LOC103032909
Zgc:158659; Belongs to the PI3/PI4-kinase family.
   
 0.951
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: medium (58%) [HD]