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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccn2Cellular communication network factor 2a. (362 aa)    
Predicted Functional Partners:
LOC103041886
Cellular communication network factor 2b.
  
  
 
0.902
ccn1
Cellular communication network factor 1.
  
  
0.665
ENSAMXP00000039033
Fibronectin 1b.
   
 
 0.627
dcn
Decorin; May affect the rate of fibrils formation.
   
  
 0.606
ENSAMXP00000042222
Heparan sulfate proteoglycan 2.
    
 
 0.606
ENSAMXP00000047894
Endothelin 1.
   
  
 0.589
LOC103026375
Ankyrin repeat domain 1a (cardiac muscle).
   
 
 0.554
tgfb1
Transforming growth factor beta; Belongs to the TGF-beta family.
   
  
 0.546
LOC103024607
Transforming growth factor beta; Belongs to the TGF-beta family.
   
  
 0.546
serpine1
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.
   
 
 0.531
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.