close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)    
Predicted Functional Partners:
map3k7
Mitogen-activated protein kinase kinase kinase 7.
   
 0.999
irak1
Interleukin-1 receptor-associated kinase 1.
   
 0.999
tab3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3.
    
 0.998
ube2n
Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.997
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.997
tab2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.996
ecsit
ECSIT signalling integrator.
    
 0.994
W5LDM9_ASTMX
TGF-beta activated kinase 1/MAP3K7 binding protein 1.
   
 0.994
map3k1
Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase.
   
 0.993
irak4
Interleukin-1 receptor-associated kinase 4.
   
 0.993
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.