W5KKG9_ASTMX protein (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

W5KKG9_ASTMX

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (646 aa)

Predicted Functional Partners:

dcaf7

0.898

Lin52

0.684

Rnf169

0.583

lin54

0.540

LOC103041235

0.540

lin37

0.531

Tp53

0.523

LOC103037427

0.523

lin9

0.509

LOC103044365

0.503

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103037427	LOC103044365	ENSAMXP00000035025	ENSAMXP00000007693	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	E1A binding protein p300 a.	0.990
LOC103037427	Tp53	ENSAMXP00000035025	ENSAMXP00000021366	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.904
LOC103037427	W5KKG9_ASTMX	ENSAMXP00000035025	ENSAMXP00000008081	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.	0.523
LOC103041235	Lin52	ENSAMXP00000045659	ENSAMXP00000031350	CRC domain-containing protein.	Lin-52 DREAM MuvB core complex component.	0.994
LOC103041235	W5KKG9_ASTMX	ENSAMXP00000045659	ENSAMXP00000008081	CRC domain-containing protein.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.	0.540
LOC103041235	lin37	ENSAMXP00000045659	ENSAMXP00000044677	CRC domain-containing protein.	Lin-37 DREAM MuvB core complex component.	0.994
LOC103041235	lin54	ENSAMXP00000045659	ENSAMXP00000027314	CRC domain-containing protein.	Lin-54 DREAM MuvB core complex component.	0.905
LOC103041235	lin9	ENSAMXP00000045659	ENSAMXP00000051609	CRC domain-containing protein.	Lin-9 DREAM MuvB core complex component.	0.994
LOC103044365	LOC103037427	ENSAMXP00000007693	ENSAMXP00000035025	E1A binding protein p300 a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.990
LOC103044365	Tp53	ENSAMXP00000007693	ENSAMXP00000021366	E1A binding protein p300 a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.990
LOC103044365	W5KKG9_ASTMX	ENSAMXP00000007693	ENSAMXP00000008081	E1A binding protein p300 a.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.	0.503
Lin52	LOC103041235	ENSAMXP00000031350	ENSAMXP00000045659	Lin-52 DREAM MuvB core complex component.	CRC domain-containing protein.	0.994
Lin52	W5KKG9_ASTMX	ENSAMXP00000031350	ENSAMXP00000008081	Lin-52 DREAM MuvB core complex component.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.	0.684
Lin52	lin37	ENSAMXP00000031350	ENSAMXP00000044677	Lin-52 DREAM MuvB core complex component.	Lin-37 DREAM MuvB core complex component.	0.998
Lin52	lin54	ENSAMXP00000031350	ENSAMXP00000027314	Lin-52 DREAM MuvB core complex component.	Lin-54 DREAM MuvB core complex component.	0.994
Lin52	lin9	ENSAMXP00000031350	ENSAMXP00000051609	Lin-52 DREAM MuvB core complex component.	Lin-9 DREAM MuvB core complex component.	0.999
Rnf169	W5KKG9_ASTMX	ENSAMXP00000032318	ENSAMXP00000008081	Ring finger protein 169.	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B.	0.583
Rnf169	dcaf7	ENSAMXP00000032318	ENSAMXP00000012270	Ring finger protein 169.	DDB1 and CUL4 associated factor 7.	0.610
Tp53	LOC103037427	ENSAMXP00000021366	ENSAMXP00000035025	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.904
Tp53	LOC103044365	ENSAMXP00000021366	ENSAMXP00000007693	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	E1A binding protein p300 a.	0.990