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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ddrgk1DDRGK domain containing 1. (148 aa)    
Predicted Functional Partners:
cdk5rap3
CDK5 regulatory subunit associated protein 3.
    
 
 0.956
ENSAMXP00000048151
UFM1-specific ligase 1.
    
 
 0.954
ufc1
Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
    
 
 0.841
ufm1
Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.
    
 
 0.771
ufsp2
Ufm1-specific peptidase 2.
    
 
 0.689
W5KFU0_ASTMX
Zinc finger protein 366.
      
 0.678
lzts3
Leucine zipper, putative tumor suppressor family member 3b.
      
 0.653
ENSAMXP00000043100
Threonine synthase-like 2.
      
 0.629
znf367
Zinc finger protein 367.
      
 0.619
ptpra
Protein tyrosine phosphatase receptor type A.
      
 0.607
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.