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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfx5Regulatory factor X, 5. (599 aa)    
Predicted Functional Partners:
ENSAMXP00000035898
Regulatory factor X-associated protein.
    
 
 0.963
rfxank
Regulatory factor X-associated ankyrin-containing protein.
   
 
 0.963
Ciita
Class II, major histocompatibility complex, transactivator.
    
 
 0.873
ENSAMXP00000051160
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.644
chek2
Checkpoint kinase 2.
   
 
 0.597
W5KU24_ASTMX
Mediator complex subunit 23.
      
 0.572
cryzl1
Crystallin, zeta (quinone reductase)-like 1.
      
 0.564
nectin1
Nectin cell adhesion molecule 1b.
      
 0.554
nfyb
Nuclear transcription factor Y, beta a.
      
 0.515
ankra2
Ankyrin repeat, family A (RFXANK-like), 2.
   
 
 0.494
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.