close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)    
Predicted Functional Partners:
ENSAMXP00000030672
Glycogen synthase kinase binding protein.
    
 0.985
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.985
LOC103034575
Catenin, beta 2.
    
 0.982
LOC103042974
Axin 2 (conductin, axil).
   
 0.982
axin1
Axin 1.
   
 0.981
axin2
Uncharacterized protein.
   
 0.980
dvl2
Dishevelled segment polarity protein 2.
   
 0.951
LOC103035729
Dishevelled segment polarity protein 1a.
   
 0.951
LOC103042896
Dishevelled segment polarity protein 3a.
   
 0.951
LOC103046093
Dishevelled segment polarity protein 1b.
   
 0.951
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.