hlcs protein (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

hlcs

Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase). (903 aa)

Predicted Functional Partners:

ENSAMXP00000044240

0.942

W5KHJ7_ASTMX

0.868

ENSAMXP00000037227

0.868

pccb

0.838

Pcca

0.828

mccc1

0.828

W5LH33_ASTMX

0.821

mccc2

0.821

ENSAMXP00000042939

0.817

ENSAMXP00000046836

0.817

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000037227	ENSAMXP00000042939	ENSAMXP00000037227	ENSAMXP00000042939	Biotin carboxylation domain-containing protein.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.582
ENSAMXP00000037227	ENSAMXP00000046836	ENSAMXP00000037227	ENSAMXP00000046836	Biotin carboxylation domain-containing protein.	Lipoyl-binding domain-containing protein.	0.582
ENSAMXP00000037227	Pcca	ENSAMXP00000037227	ENSAMXP00000000700	Biotin carboxylation domain-containing protein.	Propionyl-CoA carboxylase subunit alpha.	0.733
ENSAMXP00000037227	W5LH33_ASTMX	ENSAMXP00000037227	ENSAMXP00000019145	Biotin carboxylation domain-containing protein.	Si:ch211-198n5.11.	0.757
ENSAMXP00000037227	hlcs	ENSAMXP00000037227	ENSAMXP00000009135	Biotin carboxylation domain-containing protein.	Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase).	0.868
ENSAMXP00000037227	mccc1	ENSAMXP00000037227	ENSAMXP00000001585	Biotin carboxylation domain-containing protein.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.733
ENSAMXP00000037227	mccc2	ENSAMXP00000037227	ENSAMXP00000051198	Biotin carboxylation domain-containing protein.	Methylcrotonoyl-CoA carboxylase 2 (beta).	0.757
ENSAMXP00000037227	pccb	ENSAMXP00000037227	ENSAMXP00000035860	Biotin carboxylation domain-containing protein.	Propionyl-CoA carboxylase subunit beta.	0.758
ENSAMXP00000042939	ENSAMXP00000037227	ENSAMXP00000042939	ENSAMXP00000037227	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Biotin carboxylation domain-containing protein.	0.582
ENSAMXP00000042939	ENSAMXP00000046836	ENSAMXP00000042939	ENSAMXP00000046836	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Lipoyl-binding domain-containing protein.	0.900
ENSAMXP00000042939	Pcca	ENSAMXP00000042939	ENSAMXP00000000700	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Propionyl-CoA carboxylase subunit alpha.	0.636
ENSAMXP00000042939	W5KHJ7_ASTMX	ENSAMXP00000042939	ENSAMXP00000007059	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Acetyl-CoA carboxylase beta.	0.582
ENSAMXP00000042939	W5LH33_ASTMX	ENSAMXP00000042939	ENSAMXP00000019145	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Si:ch211-198n5.11.	0.722
ENSAMXP00000042939	hlcs	ENSAMXP00000042939	ENSAMXP00000009135	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase).	0.817
ENSAMXP00000042939	mccc1	ENSAMXP00000042939	ENSAMXP00000001585	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.637
ENSAMXP00000042939	mccc2	ENSAMXP00000042939	ENSAMXP00000051198	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Methylcrotonoyl-CoA carboxylase 2 (beta).	0.722
ENSAMXP00000042939	pccb	ENSAMXP00000042939	ENSAMXP00000035860	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	Propionyl-CoA carboxylase subunit beta.	0.740
ENSAMXP00000044240	hlcs	ENSAMXP00000044240	ENSAMXP00000009135	Biotinidase.	Holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase).	0.942
ENSAMXP00000046836	ENSAMXP00000037227	ENSAMXP00000046836	ENSAMXP00000037227	Lipoyl-binding domain-containing protein.	Biotin carboxylation domain-containing protein.	0.582
ENSAMXP00000046836	ENSAMXP00000042939	ENSAMXP00000046836	ENSAMXP00000042939	Lipoyl-binding domain-containing protein.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.900