hmces protein (Astyanax mexicanus) - STRING interaction network

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hmces

Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (358 aa)

Predicted Functional Partners:

rfwd3

0.577

Sprtn

0.577

smarcal1

0.567

ssbp1

0.556

rcl1

0.464

tipin

0.426

LOC103034699

0.426

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103034699	hmces	ENSAMXP00000045539	ENSAMXP00000009412	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.426
LOC103034699	rfwd3	ENSAMXP00000045539	ENSAMXP00000014138	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Ring finger and WD repeat domain 3.	0.443
LOC103034699	smarcal1	ENSAMXP00000045539	ENSAMXP00000003415	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.490
Sprtn	hmces	ENSAMXP00000042904	ENSAMXP00000009412	SprT-like N-terminal domain.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.577
Sprtn	smarcal1	ENSAMXP00000042904	ENSAMXP00000003415	SprT-like N-terminal domain.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.456
hmces	LOC103034699	ENSAMXP00000009412	ENSAMXP00000045539	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.426
hmces	Sprtn	ENSAMXP00000009412	ENSAMXP00000042904	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	SprT-like N-terminal domain.	0.577
hmces	rcl1	ENSAMXP00000009412	ENSAMXP00000028077	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	RNA terminal phosphate cyclase-like 1.	0.464
hmces	rfwd3	ENSAMXP00000009412	ENSAMXP00000014138	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Ring finger and WD repeat domain 3.	0.577
hmces	smarcal1	ENSAMXP00000009412	ENSAMXP00000003415	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.567
hmces	ssbp1	ENSAMXP00000009412	ENSAMXP00000034769	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	Single-stranded DNA binding protein 1.	0.556
hmces	tipin	ENSAMXP00000009412	ENSAMXP00000036086	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.426
rcl1	hmces	ENSAMXP00000028077	ENSAMXP00000009412	RNA terminal phosphate cyclase-like 1.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.464
rcl1	ssbp1	ENSAMXP00000028077	ENSAMXP00000034769	RNA terminal phosphate cyclase-like 1.	Single-stranded DNA binding protein 1.	0.430
rfwd3	LOC103034699	ENSAMXP00000014138	ENSAMXP00000045539	Ring finger and WD repeat domain 3.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.443
rfwd3	hmces	ENSAMXP00000014138	ENSAMXP00000009412	Ring finger and WD repeat domain 3.	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]	0.577
rfwd3	smarcal1	ENSAMXP00000014138	ENSAMXP00000003415	Ring finger and WD repeat domain 3.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.683
rfwd3	tipin	ENSAMXP00000014138	ENSAMXP00000036086	Ring finger and WD repeat domain 3.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.443
smarcal1	LOC103034699	ENSAMXP00000003415	ENSAMXP00000045539	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.490
smarcal1	Sprtn	ENSAMXP00000003415	ENSAMXP00000042904	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	SprT-like N-terminal domain.	0.456

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