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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLSPNClaspin. (1293 aa)    
Predicted Functional Partners:
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
   
 0.985
W5KFH6_ASTMX
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.982
rpa1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.977
rpa3
Uncharacterized protein.
    
 0.974
mcm2
DNA helicase; Belongs to the MCM family.
   
 0.969
timeless
Timeless circadian clock.
   
 
 0.966
primpol
Primase and polymerase (DNA-directed).
   
 
 0.946
mcm5
DNA helicase; Belongs to the MCM family.
   
 0.928
Mcm4
DNA helicase; Belongs to the MCM family.
   
 0.922
gins3
GINS complex subunit 3.
   
 
 0.915
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.