NTHL1 protein (Astyanax mexicanus) - STRING interaction network

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NTHL1

Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (264 aa)

Predicted Functional Partners:

apex1

0.942

apex2

0.915

LOC103025298

0.910

neil3

0.892

fancm

0.797

ENSAMXP00000037285

0.788

gart

0.769

W5LSN0_ASTMX

0.751

LOC103032585

0.751

ENSAMXP00000032690

0.751

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAMXP00000032690	LOC103025298	ENSAMXP00000032690	ENSAMXP00000034609	Reverse transcriptase domain-containing protein.	Si:ch211-141o9.10.	0.666
ENSAMXP00000032690	NTHL1	ENSAMXP00000032690	ENSAMXP00000010693	Reverse transcriptase domain-containing protein.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.751
ENSAMXP00000032690	fancm	ENSAMXP00000032690	ENSAMXP00000020881	Reverse transcriptase domain-containing protein.	Uncharacterized protein.	0.605
ENSAMXP00000037285	LOC103025298	ENSAMXP00000037285	ENSAMXP00000034609	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Si:ch211-141o9.10.	0.415
ENSAMXP00000037285	NTHL1	ENSAMXP00000037285	ENSAMXP00000010693	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.788
ENSAMXP00000037285	fancm	ENSAMXP00000037285	ENSAMXP00000020881	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Uncharacterized protein.	0.722
ENSAMXP00000037285	gart	ENSAMXP00000037285	ENSAMXP00000040491	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.433
ENSAMXP00000037285	neil3	ENSAMXP00000037285	ENSAMXP00000015818	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Nei-like DNA glycosylase 3.	0.415
LOC103025298	ENSAMXP00000032690	ENSAMXP00000034609	ENSAMXP00000032690	Si:ch211-141o9.10.	Reverse transcriptase domain-containing protein.	0.666
LOC103025298	ENSAMXP00000037285	ENSAMXP00000034609	ENSAMXP00000037285	Si:ch211-141o9.10.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.415
LOC103025298	LOC103032585	ENSAMXP00000034609	ENSAMXP00000030537	Si:ch211-141o9.10.	Uncharacterized protein.	0.666
LOC103025298	NTHL1	ENSAMXP00000034609	ENSAMXP00000010693	Si:ch211-141o9.10.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.910
LOC103025298	W5LSN0_ASTMX	ENSAMXP00000034609	ENSAMXP00000025985	Si:ch211-141o9.10.	Endo/exonuclease/phosphatase domain-containing protein.	0.666
LOC103025298	apex1	ENSAMXP00000034609	ENSAMXP00000052378	Si:ch211-141o9.10.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.990
LOC103025298	apex2	ENSAMXP00000034609	ENSAMXP00000007627	Si:ch211-141o9.10.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.988
LOC103025298	fancm	ENSAMXP00000034609	ENSAMXP00000020881	Si:ch211-141o9.10.	Uncharacterized protein.	0.954
LOC103025298	gart	ENSAMXP00000034609	ENSAMXP00000040491	Si:ch211-141o9.10.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.555
LOC103025298	neil3	ENSAMXP00000034609	ENSAMXP00000015818	Si:ch211-141o9.10.	Nei-like DNA glycosylase 3.	0.729
LOC103032585	LOC103025298	ENSAMXP00000030537	ENSAMXP00000034609	Uncharacterized protein.	Si:ch211-141o9.10.	0.666
LOC103032585	NTHL1	ENSAMXP00000030537	ENSAMXP00000010693	Uncharacterized protein.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.751

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