angel2 protein (Astyanax mexicanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

angel2

Angel homolog 2 (Drosophila). (556 aa)

Predicted Functional Partners:

toe1

0.508

PAN2

0.480

katnal2

0.438

rps6kc1

0.433

OTOL1

0.432

bend7

0.429

pan3

0.404

nsun6

0.403

Your Current Organism:

Astyanax mexicanus

NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OTOL1	angel2	ENSAMXP00000019585	ENSAMXP00000010793	Otolin 1a.	Angel homolog 2 (Drosophila).	0.432
OTOL1	bend7	ENSAMXP00000019585	ENSAMXP00000035853	Otolin 1a.	Si:ch211-220f12.4.	0.578
OTOL1	katnal2	ENSAMXP00000019585	ENSAMXP00000045581	Otolin 1a.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.578
OTOL1	rps6kc1	ENSAMXP00000019585	ENSAMXP00000012581	Otolin 1a.	Ribosomal protein S6 kinase polypeptide 1.	0.577
PAN2	angel2	ENSAMXP00000005548	ENSAMXP00000010793	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	Angel homolog 2 (Drosophila).	0.480
PAN2	pan3	ENSAMXP00000005548	ENSAMXP00000014780	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]	0.999
PAN2	toe1	ENSAMXP00000005548	ENSAMXP00000038819	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	Target of EGR1, exonuclease.	0.579
angel2	OTOL1	ENSAMXP00000010793	ENSAMXP00000019585	Angel homolog 2 (Drosophila).	Otolin 1a.	0.432
angel2	PAN2	ENSAMXP00000010793	ENSAMXP00000005548	Angel homolog 2 (Drosophila).	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.480
angel2	bend7	ENSAMXP00000010793	ENSAMXP00000035853	Angel homolog 2 (Drosophila).	Si:ch211-220f12.4.	0.429
angel2	katnal2	ENSAMXP00000010793	ENSAMXP00000045581	Angel homolog 2 (Drosophila).	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.438
angel2	nsun6	ENSAMXP00000010793	ENSAMXP00000048708	Angel homolog 2 (Drosophila).	NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.403
angel2	pan3	ENSAMXP00000010793	ENSAMXP00000014780	Angel homolog 2 (Drosophila).	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]	0.404
angel2	rps6kc1	ENSAMXP00000010793	ENSAMXP00000012581	Angel homolog 2 (Drosophila).	Ribosomal protein S6 kinase polypeptide 1.	0.433
angel2	toe1	ENSAMXP00000010793	ENSAMXP00000038819	Angel homolog 2 (Drosophila).	Target of EGR1, exonuclease.	0.508
bend7	OTOL1	ENSAMXP00000035853	ENSAMXP00000019585	Si:ch211-220f12.4.	Otolin 1a.	0.578
bend7	angel2	ENSAMXP00000035853	ENSAMXP00000010793	Si:ch211-220f12.4.	Angel homolog 2 (Drosophila).	0.429
bend7	katnal2	ENSAMXP00000035853	ENSAMXP00000045581	Si:ch211-220f12.4.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.578
bend7	rps6kc1	ENSAMXP00000035853	ENSAMXP00000012581	Si:ch211-220f12.4.	Ribosomal protein S6 kinase polypeptide 1.	0.578
katnal2	OTOL1	ENSAMXP00000045581	ENSAMXP00000019585	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Otolin 1a.	0.578