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The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103025523Retinoic acid receptor, alpha b. (455 aa)    
Predicted Functional Partners:
med1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.728
W5LKA6_ASTMX
Nuclear receptor corepressor 1.
    
 0.676
Ncor2
Nuclear receptor corepressor 2.
    
 0.676
W5KHI0_ASTMX
Retinoid X receptor, alpha a.
   
0.616
LOC103046247
Retinoid x receptor, alpha b.
   
0.616
W5LKG1_ASTMX
Retinoid x receptor, beta a.
   
0.608
LOC103038456
Retinoid X receptor, gamma b.
   
0.608
LOC103033918
Uncharacterized protein.
   
0.608
LOC103040717
Retinoid x receptor, beta b.
   
0.608
LOC103046225
Nuclear receptor subfamily 1, group D, member 2a.
   
0.569
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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