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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103027415Interferon regulatory factor. (310 aa)    
Predicted Functional Partners:
Mdm2
MDM2 proto-oncogene.
    
 0.939
ENSAMXP00000029669
Interferon regulatory factor 2.
  
0.813
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.777
LOC103044365
E1A binding protein p300 a.
    
 0.768
ep300
E1A binding protein p300 b.
    
 0.768
W5L336_ASTMX
Signal transducer and activator of transcription.
   
 0.722
spi1
Spi-1 proto-oncogene b.
   
 
 0.692
Stub1
STIP1 homology and U-Box containing protein 1.
    
 
 0.681
ENSAMXP00000053288
Proteasome subunit beta.
   
  
 0.661
LOC103021920
JunE proto-oncogene, AP-1 transcription factor subunit.
   
 0.652
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.