Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
aplp1Amyloid beta (A4) precursor-like protein 1. (725 aa)    
Predicted Functional Partners:
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
    
 0.794
fkrp
Fukutin related protein.
     
 0.778
Sorl1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.775
dab1
DAB adaptor protein 1a.
    
 
 0.763
LOC103046668
Amyloid beta (A4) precursor protein b.
    
 
 0.755
APP
Amyloid beta precursor protein.
    
 
 0.755
App
BPTI/Kunitz inhibitor domain-containing protein.
    
 
 0.755
lrp3
Low density lipoprotein receptor-related protein 3.
    
 0.738
lrp10
Low density lipoprotein receptor-related protein 10.
    
 0.738
sdhaf1
Uncharacterized protein; Belongs to the complex I LYR family.
      
 0.728
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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