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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103021407Signal transducer and activator of transcription. (830 aa)    
Predicted Functional Partners:
jak1
Tyrosine-protein kinase.
   
 0.975
LOC103044144
Tyrosine-protein kinase.
   
 0.975
W5L336_ASTMX
Signal transducer and activator of transcription.
  
 
0.973
LOC103031000
Signal transducer and activator of transcription.
  
 
0.957
ENSAMXP00000037526
SH2 domain-containing protein.
  
 
0.956
W5KBS6_ASTMX
Interferon regulatory factor 9.
   
 0.914
LOC103027049
Tyrosine-protein kinase.
   
 0.885
jak2
Tyrosine-protein kinase.
   
 0.865
ENSAMXP00000028686
Protein kinase domain-containing protein.
   
 0.773
ENSAMXP00000047948
FERM domain-containing protein.
   
 0.773
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.