close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Huwe1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (2545 aa)    
Predicted Functional Partners:
ENSAMXP00000033469
HECT domain-containing protein.
 
     0.927
UBB
Ubiquitin B.
   
 0.842
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.838
rps27a
Ribosomal protein S27a.
   
 0.798
Trip12
Thyroid hormone receptor interactor 12.
   
 
0.754
ENSAMXP00000039594
Uncharacterized protein.
   
 
 0.754
LOC111197410
Uncharacterized protein.
    
 
 0.724
ENSAMXP00000038752
Uncharacterized protein.
    
 
 0.724
LOC103046057
MCL1 apoptosis regulator, BCL2 family member b.
    
 
 0.724
ddit4
DNA-damage-inducible transcript 4.
    
   0.684
Your Current Organism:
Astyanax mexicanus
NCBI taxonomy Id: 7994
Other names: A. mexicanus, Mexican tetra, blind cave fish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.