Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
usp28Ubiquitin carboxyl-terminal hydrolase 28; Belongs to the peptidase C19 family. (1181 aa)    
Predicted Functional Partners:
trip12
E3 ubiquitin-protein ligase TRIP12.
   
 
 0.903
tp53bp1
Tumor suppressor p53-binding protein 1 isoform X3.
   
 
 0.844
rps27a
Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]
   
 0.782
CLSPN
Claspin.
    
 0.738
uba52
ubiquitin-60S ribosomal protein L40 isoform X1.
   
  0.736
usp10
Ubiquitin carboxyl-terminal hydrolase.
   
 
 0.736
rad23b
UV excision repair protein RAD23 homolog B.
   
 0.686
LOC108271249
UV excision repair protein RAD23 homolog A-like isoform X1.
   
 0.686
ddx58
Probable ATP-dependent RNA helicase DDX58.
   
 
 0.673
LOC108268289
Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
    
 0.670
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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