Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC108265726Mitogen-activated protein kinase. (361 aa)    
Predicted Functional Partners:
mapkapk2
MAP kinase-activated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily.
  
0.986
LOC108274084
Dual specificity mitogen-activated protein kinase kinase 6 isoform X1.
  
0.985
LOC108281044
MAP kinase-activated protein kinase 3-like; Belongs to the protein kinase superfamily.
  
0.980
cdc25b
M-phase inducer phosphatase 2.
    
 0.973
mapkapk5
MAP kinase-activated protein kinase 5.
   
0.969
atf2
Cyclic AMP-dependent transcription factor ATF-2.
    
 0.966
mef2c
Myocyte-specific enhancer factor 2C isoform X1.
    
 0.964
LOC108267915
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.964
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
   
 0.964
LOC108260350
Ribosomal protein S6 kinase.
   
 
0.963
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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