Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
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[Homology]
Score
LOC108276197Cyclin-dependent kinase-like 5 isoform X1. (1002 aa)    
Predicted Functional Partners:
mecp2
methyl-CpG-binding protein 2 isoform X2.
    
 
 0.770
fmr1
Fragile X mental retardation protein 1 isoform X1.
    
 
 0.628
ntng1
netrin-G1 isoform X2.
      
 0.543
prune1
Protein prune homolog isoform X1.
      
 0.465
pcdh19
Protocadherin-19 isoform X1.
      
 0.443
ube3a
Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
      
 0.430
stxbp1
Syntaxin-binding protein 1 isoform X2; Belongs to the STXBP/unc-18/SEC1 family.
      
 0.408
PDZD4
PDZ domain-containing protein 4 isoform X2.
      
 0.407
sptan1
Spectrin alpha chain, non-erythrocytic 1 isoform X6.
      
 0.403
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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