Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rb1Retinoblastoma-associated protein. (902 aa)    
Predicted Functional Partners:
e2f1
Transcription factor E2F1.
   
 0.999
skp2
S-phase kinase-associated protein 2.
   
 0.998
mdm2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
   
 0.997
e2f3
Transcription factor E2F3.
   
 0.991
CCNE2
G1/S-specific cyclin-E2-like; Belongs to the cyclin family.
   
 0.991
ccna1
cyclin-A1 isoform X2; Belongs to the cyclin family.
   
 0.991
e2f2
Transcription factor E2F2 isoform X2.
   
 0.991
ccne1
G1/S-specific cyclin-E1 isoform X2; Belongs to the cyclin family.
   
 0.991
LOC108272398
Transcription factor E2F3-like.
   
 0.991
ccna2
cyclin-A2; Belongs to the cyclin family.
   
 0.991
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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