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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psenenPresenilin enhancer, gamma-secretase subunit. (66 aa)    
Predicted Functional Partners:
ncstn
Nicastrin.
    
 0.997
LOC108269999
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.975
LOC108271374
Gamma-secretase subunit Aph-1b.
   
 0.973
LOC108258586
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.971
LOC100304952
Gamma-secretase subunit Aph-1b.
   
 0.966
LOC108258852
Amyloid beta A4 protein-like isoform X1.
    
 0.745
LOC108266463
Amyloid beta A4 protein-like isoform X1.
    
 0.745
LOC108279276
Neurogenic locus notch homolog protein 1-like.
    
 0.681
LOC108255797
Neurogenic locus notch homolog protein 1-like.
    
 0.681
tmed10
Transmembrane emp24 domain-containing protein 10.
    
 
 0.604
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.