Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC108272942Trinucleotide repeat-containing gene 6B protein-like isoform X3. (1456 aa)    
Predicted Functional Partners:
LOC108256363
Protein argonaute-1; Belongs to the argonaute family.
    
 0.616
ago2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 0.563
LOC108272767
Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.
    
 0.563
LOC108257199
Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.
    
 0.563
ENSIPUP00000034611
Argonaute RISC catalytic component 3a.
    
 0.563
LOC108277040
PERQ amino acid-rich with GYF domain-containing protein 1-like isoform X4.
    
 
 0.528
dicer1
Endoribonuclease Dicer isoform X2; Belongs to the helicase family. Dicer subfamily.
    
 
 0.493
edc3
Enhancer of mRNA-decapping protein 3.
      
 0.480
cnot1
CCR4-NOT transcription complex subunit 1 isoform X2.
   
 
 0.450
gigyf1
PERQ amino acid-rich with GYF domain-containing protein 1 isoform X1.
    
 
 0.410
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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