Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hdac8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (407 aa)    
Predicted Functional Partners:
arid4a
AT-rich interactive domain-containing protein 4A.
   
 0.919
arid4b
AT-rich interactive domain-containing protein 4B isoform X2.
   
 0.919
kdm1a
Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.
   
 0.918
mecp2
methyl-CpG-binding protein 2 isoform X2.
    
 0.883
sap30l
Histone deacetylase complex subunit SAP30L.
    
 0.872
smc3
Structural maintenance of chromosomes protein.
  
 0.870
rbbp7
Histone-binding protein RBBP7 isoform X1.
   
 0.866
suds3
LOW QUALITY PROTEIN: sin3 histone deacetylase corepressor complex component SDS3.
    
 0.866
rbbp4
Histone-binding protein RBBP4.
   
 0.866
dnmt1
DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.862
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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