Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (302 aa)    
Predicted Functional Partners:
ccnd1
G1/S-specific cyclin-D1; Belongs to the cyclin family.
   
 0.997
LOC108263810
Cyclin-dependent kinase 4 inhibitor B-like.
    
 0.991
ccnd2
G1/S-specific cyclin-D2; Belongs to the cyclin family.
   
 0.990
rb1
Retinoblastoma-associated protein.
   
 0.985
LOC108279704
G1/S-specific cyclin-D2-like; Belongs to the cyclin family.
   
 0.984
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.983
cdkn1a
Cyclin-dependent kinase inhibitor 1 isoform X1.
   
 0.981
rbl1
Retinoblastoma-like protein 1.
   
 0.980
rbl2
Retinoblastoma-like protein 2 isoform X3.
   
 0.980
cdkn2c
Cyclin-dependent kinase 4 inhibitor C.
   
 0.977
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
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