Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
avilAdvillin. (827 aa)    
Predicted Functional Partners:
cog6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
   
 
 0.640
cog8
Conserved oligomeric Golgi complex subunit 8.
    
 
 0.631
cog3
Conserved oligomeric Golgi complex subunit 3.
    
 
 0.625
rce1
CAAX prenyl protease 2.
    
   0.477
get3
ATPase asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]
   
   0.470
LOC108271360
Conserved oligomeric Golgi complex subunit 4-like.
    
 
 0.448
gfod2-2
Glucose-fructose oxidoreductase domain-containing protein 2 isoform X2.
    
 
 0.448
smim7
Upf0608 protein c19orf42-like protein.
    
 
 0.448
LOC108273092
Peripheral plasma membrane protein CASK-like isoform X9; Belongs to the MAGUK family.
   
  0.447
LOC108264495
Tropomodulin-2-like.
    
 
 0.447
Your Current Organism:
Ictalurus punctatus
NCBI taxonomy Id: 7998
Other names: I. punctatus, Silurus punctatus, channel catfish
Server load: medium (76%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.